UDVA remained stable in all cases of myopic eyes at six months and the percentage increased at 92.0% in myopic eyes. What Refractive Errors Can SMILE Correct? 2015;41:2136–44. [25], in their review upon ectasia after 750,000 SMILE procedures performed worldwide, reported only seven eyes with ectasia. For all interventions, the VisuMax femtosecond laser system (Carl Zeiss Meditec, Jena, Germany) was used. Medically Reviewed by Dr. Melody Huang, O.D. Previous studies have demonstrated that SMILE is safe and effective for the management of myopia and myopic astigmatism [13, 14, 16, 22]. 2017;10(9):1436–45. Liu YC, Jayawinghe L, Ang HP, Lwin NC, Yam GH, Mehta JS. What is ReLEx SMILE. Google Scholar. Prices for ReLEx SMILE surgery start at approximately £2,000 per . The value of cylinder decreased postoperatively on myopic astigmatic eyes with a median of -0.50 D at one month, -0.25 D at six months and -0.50 D at 12 months. Similar results showed Han et al. Long-term studies also indicate that SMILE has excellent outcomes combined with high safety. All patients with ocular intervention from September 2018 to December 2018 were eligible for the study. The lamellar incision area is roughly 1/3 smaller than for Femto-LASIK treatment. 2014;30:590–6. Further research is necessary to understand the long-term outcomes of SMILE. SMILE is the latest in laser vision correction for myopia. Some studies demonstrated a delay in the visual recovery and visual fluctuations with episodes of blurring of vision in the early postoperative period after SMILE compared to LASIK [37, 38]. A femtosecond laser will create a thin layer, the shape of a contact lens, inside the intact cornea. At 12 months, 80% of myopic eyes were within ±0.5D from the target and 88% were within±1 D. At 12 months 43.3%, the myopic astigmatic eyes were maintained within ±0.5 D cases and 73.1% within ±1D. [20] in their study of 4 years refractive outcomes, wavefront aberrations and quality of life after SMILE for moderate-to-high myopia (mean SE - 6.30 ± 1.47 D) concluding that SMILE provides a predictable and stable correction, with no significant changes of MRSE during postoperative follow-ups up to 4 years. The laser settings used for expert and standard mode are represented in Table 2 and the surgical parameters used during SMILE are given in Table 3. Pada ReLEx® SMILE tidak perlu dibuat flap di kornea yang biasa dilakukan pada prosedur LASIK. Here is a 2 year update from. 1st ed; 2015. the gentlest form of laser eye surgery. 2012;28:865–71. SMILE is becoming more and more popular as a flapless and minimally invasive form of laser vision correction for the treatment of myopia and myopic astigmatism using only one type of laser (femtosecond laser) for the entire surgery. ใช้ Visumax Femtosecond Laser แยกชั้นกระจกตาให้เป็นเลนส์ในเนื้อกระจกตา (Lenticule) เพื่อปรับความโค้งของกระจกตา * ให้ . The Kflat, Ksteep, and Kmean values decreased significantly one month postoperatively and showed similar values at 12 months follow-up on both groups (P-values<0.0001). Kim JR, Hwang HB, Mun SJ, Chung YT, Kim HS. Furthermore, no significant differences were observed when 1-month follow-up was compared to 12 months follow-up (Wilcoxon pairs test: Statistics = 1.78, P-value = 0.0754) or 6 months follow-up was compared to 12 months follow-up (Wilcoxon pairs test: Statistics = 0.53, P-value = 0.5930). Wu W, Wang Y, Zhang H, Zhang J, Li H, Dou R, et al. Provided by the Springer Nature SharedIt content-sharing initiative. By using this website, you agree to our The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. Flapless: Tidak akan terjadi komplikasi yang berhubungan dengan flap, seperti flap bergeser ataupun flap berkerut. 2014;157:128–34.e2. ReLEX is an alternative to keratomileusis in situ (LASIK) to correct myopia and myopic astigmatism done in 1990 for the first time by Pallikaris et al. 30 The intended thickness of the upper tissue arcade (the cap) was 120 mm, with an intended diameter of 7.5 mm, whereas the average diameter of the refractive lenticule was 6.37±0.44 mm (from 6.0 to 7.0 mm). Ini versi tertulisnya ya, kalau kalian lebih suka nonton video, kalian bisa nonton disini di channel YouTubeku ya!. DN participated in surgeries, made the analysis and interpretation of data. The percentage of eyes, both myopic and myopic astigmatic eyes, within ±0.50 D showed no significant difference between 6 months and 12 months follow-up (P-values >0.9999). ReLEx® SMILE uses only one type of laser ( a femtosecond laser) to separate inner corneal tissue to be a 3D shape (lenticule). Turk J Ophthalmol. ZEISS ReLEx SMILE is the first minimally invasive, Small Incision Lenticule Extraction solution - redefines refractive surgery. Other complications in our study were recorded in 22.82% eyes, which included a minor epithelial abrasion in ten eyes (9.2%), small tears at the incision in 8 eyes (8.69%). An alternative to SMILE is LASIK (laser-assisted in situ keratomileusis). This might be as a result of suboptimal laser photo-disruption of the stromal fibers that further causes interface scattering due to traumatic dissection [39], micro-distortions in Bowman’s layer after lenticule removal [40], and transient increased stromal keratocyte activity at the interface resulting from the stromal pocket irrigation [41]. The surgery has many advantages over other types of laser treatments, including a faster and less uncomfortable recovery and an extremely low risk of complication. Google Scholar. This associates with at least sixteen times . [24], who obtained a safety index of 1.00 at 3 and 6 months after SMILE and Ivarsen et al. Myopia can occur when the eye focuses light directly in front of the retina. Nicula, C.A., Nicula, D., Bolboacă, S.D. So I had it done in March 2021 at Manhattan Lasik Center. Friedman showed statistically differences among follow-up examination (Statistics = 178.96, P-value < 0.0001), with statistically significance differences when the baseline is compared with each follow-up (P-values = 0.00001). Leucovorin and MTX are structural analogues, possibly competing for cellular transport and intracellular metabolism. The achieved correction versus the attempted refractive correction at 12 months was analysed with a linear regression model under the assumption of a normal distribution of refractive correction at 12 months. Sekundo et al. [12] could be explained by the presence of patients younger than 25 years in our sample on who we performed an extra correction of 0.25-0.5 D. Moshirfar et al. ReLEx® SMILE is the process in which the lenticule is removed mechanically through a small incision, whereas in LASIK a femtosecond laser is used to cut a corneal flap. ReLEX is an alternative to keratomileusis in situ (LASIK) to correct myopia and myopic astigmatism done in 1990 for the first time by Pallikaris et al. ReLEx SMILE Lentivu is small incision lenticule extraction. The lower results on myopic eyes in our study than the results reported by Sekundo et al. เลสิก. With ReLex® SMILE myopia up to a max. Millions have been helped by PRK and LASIK. The intraoperative problems during SMILE surgery include the loss of suction, the occurrence of altered or irregular opaque bubble layer and black spots, difficulty in lenticular dissection and extraction, cap perforation, incision-related problems, and decentered ablation. SMILE® from ZEISS enables the first Small Incision Lenticule Extraction procedure for minimally invasive laser vision correction. volume 21, Article number: 423 (2021) But the majority of people can carry out most of their day-to-day tasks without them. Manual extraction of the lenticule by the surgeon to correct the refractive error. 1. Just as the name suggests, it's a minimally invasive procedure to correct astigmatism and short-sightedness. No significant changes in the safety index was observed in myopic eyes (P-value > 0.9999) and in myopic astigmatic eyes (P-value = 0.1146). (Daher wird auch gerne der Begriff 3D-Augenlasern für Relex Smile verwendet . This is predominantly because the equipment which performs the surgery is more advanced and expensive. SMILE surgery uses a femtosecond laser, or a high-speed, short-pulsed laser, to remove a section of the cornea. would also be clinically relevant in the assessment of the long-term effectiveness of this technique. [26], in a study on 1800 eyes, reported an incidence of 6% of epithelial abrasions,1.8% of small incision tears, 1.9% difficult lenticule extraction, 0.22% cap perforation and 0.06% of major tear. Sure enough, my eyesight had suddenly deteriorated - a lot. Shah R, Shah S, Sengupta S. Results of small incision lenticule extraction: all-in-one femtosecond laser refractive surgery. The follow-up period was 12 months and all patients completed all follow-ups (one, six, and twelve months). Statistica program (v. 13, StatSoft, USA) was used for statistical analysis and all applied tests were two-tail. Wu et al. If you are a citizen from the US, please visit your country website for local information and contacts. ReLEx SMILE eye surgery stands for refractive lenticule extraction small incision lenticule extraction surgery. Similarly, significant differences were observed when EI at 1 month was compared to EI at 6-months (Wilcoxon Matched Pairs Test: Statistic = 3.06, P-value = 0.0022, n=12) and EI at 12-months (Wilcoxon Matched Pairs Test: Statistic = 3.30, P-value = 0.0010, n=14) on myopic astigmatic eyes. Most people will have hazy vision right after the procedure. Proses operasinya hanya beberapa menit saja dan begitu selesai operasi, penglihatan akan mencapi 80% serta akan mencapai 100% dalam . Intraocular lenses (IOLs) and OVD portfolio, Optical coherence tomography (OCT) systems, ZEISS Phacoemulsification, Lens Fragmentation and Surgical Packs, Software module for Small Incision Lenticule Extraction. Sedikit backstory dulu nih, buat kalian yang nggak tahu, aku minus sudah dari kelas 2 SD (sekarang aku umur 22), jadi sudah lama . Int J Ophthalmol. [1] It has been described as a painless procedure. This occurs when people can see things clearly close up but are unable to see things clearly from a distance. Vision-related quality of life and visual outcomes after small-incision lenticule extraction and laser in situ keratomileusis. Ganesh S, Gupta R. Comparison of visual and refractive outcomes following femtosecond laser-assisted lasik with smile in patients with myopia or myopic astigmatism. [2] ReLEX SMILE is exclusively performed with one laser, a femtosecond laser that ensures high-level reproducibility and predictability, even with high corrections [2,3,4]. After one week, we reoperate, ending with the extraction of the lenticule and visual acuity recovery. One year outcomes after small incision lenticule extraction ReLEX in the correction of myopia and myopic astigmatism, https://doi.org/10.1186/s12886-021-02195-9, Small Incision Lenticule Extraction (SMILE), http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/. SMILE technique demonstrated very good outcomes in terms of keratometric, cylinder, spherical measurements. Article Age: 24. The information provided on VisionCenter.org should not be used in place of actual information provided by a doctor or a specialist. Uncorrected visual acuity, postoperative astigmatism, and dry eye symptoms are major determinants of patient satisfaction: a comparative, real-life study of femtosecond laser in situ keratomileusis and small incision lenticule extraction for myopia. Computer-controlled application of laser pulses to create lenticule planes. This site features our entire product portfolio worldwide. Material and methods: A non-randomized clinical study has been conducted on patients with myopia and myopic astigmatism who underwent ReLEX SMILE technique, using the Zeiss VisuMax Laser system (Carl . Three-year results of small incision lenticule extraction for high myopia: Refractive outcomes and aberrations. [2] The procedure involves using a femtosecond laser to create a corneal lenticule which is extracted whole through a small incision without the use of an excimer laser. Because SMILE is relatively new, most surgeons recommend LASIK instead. to get direct assistance from our service team. ReLEx® SMILE (katanya dan ternyata memang iya!) BMJ Open. [4], After the femtosecond laser has separated the lenticule, a blunt spatula is inserted through the incision between the lenticule and the stroma and carefully rotated to ensure that the lenticule is completely detached prior to removal by forceps. Similar results were shown by Pedersen et al. The postoperative mean sphere proved significantly smaller values than baseline for each investigated follow-up (Wilcoxon test: P-values=0.00001). Support Lucile Packard Children's Hospital Stanford and child and maternal health. Ganesh et al. Before surgery, your ophthalmologist will talk through expectations. PubMed The association between the achieved and the attempted refractive correction at 12 months after the procedure is presented in Fig. Generation of access cut through which the lenticule is extracted. Looking for an opportunity to expand your career? ReLEX SMILE has the advantages of better ocular surface stability and biomechanical strength compared with femto-LASIK techniques [4,5,6,7]. The association analysis between values of CDVA and keratometry measurements was evaluated with Spearman’s rank correlation coefficient at a significance level of 5%, and any correlation coefficient with P-values less than 0.05 were considered statistically significant. Clinical outcomes after SMILE and femtosecond laser-assisted LASIK for myopia and myopic astigmatism: a prospective randomized comparative study. EuroEyes beantwortet diese und weitere Fragen rund um das ReLEx smile-Verfahren.Weitere informati. Sachdev G, Sachdev MS, Sachdev R, Gupta H. Unilateral corneal ectasia following small-incision lenticule extraction. So a little background info -. We hypothesize that Leucovorin accumulates during consecutive courses, which might result . .” Canadian Journal of Ophthalmology. For candidates to qualify for this treatment, they have their corneal stroma thickness checked to make sure that post operative thickness won't be too thin. J Cataract Refract Surg. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. J Cataract Refract Surg. Br J Ophthalmol. We may earn commissions if you purchase something via one of our links. Reinstein DZ, Archer TJ, Gobbe M. Lenticule thickness readout for small incision lenticule extraction compared to Artemis three-dimensional very high-frequency digital ultrasound stromal measurements. Han T, Zheng K, Chen Y, Gao Y, He L, Zhou X, et al. With ZEISS SMILE, only a small incision of 2 mm is sufficient, meaning that the majority of the upper corneal layers remains untouched. Research suggests there is a nonsignificant reduction in postoperative tear production for people who undergo SMILE. 6, 400349, Cluj-Napoca, Romania, Department of Pathophysiology, “Iuliu Hațieganu” University of Medicine and Pharmacy, Victor Babeș Str., no. Moshirfar et al. Approved labeling and instructions may vary from one country to another. Article The intervention with the femtosecond laser platform is minimally invasive and is the latest advancement in laser vision correction of myopia and myopic astigmatism. The value of sphere decreased postoperatively on myopic eyes with a median of -0.25D (IQR = (-0.75 to 0.00)) at 1 month, -0.25 D (IQR = (-0.50 to -0.25) at 6 months and -0.25 D (IQR = (-0.50 to 0.00) at 12 months. After the laser treatment, all patients underwent topical antibiotics and steroids (Tobramicine and Dexamethasone eye drops) five times daily for three days (NOVATIS PHARMA GMBH - GERMANIA), four times daily for one month with the tapered dose and artificial tears two times daily for 2 to 3 months. Kamiya K, Shimizu K, Igarashi A, Kobashi H. Visual and refractive outcomes of femtosecond lenticule extraction and small-incision lenticule extraction for myopia. ini metode paling cepat, nggak sakit karena sayatannya kecil, otomatis pemulihannya cepat. A low pulse energy is generally associated with fewer unwanted side effects (such as opaque bubble layer, collateral thermal damage, corneal inflammation) [4]. Yan H, Gong LY, Huang W, Peng YL. Friedman test showed significant differences among follow-ups (Statistic = 138.32, P-value<0.0001). 2016;100:1192–5. SMILE is the abbreviation for Small Incision Lenticule Extraction. All eyes aimed for the correction of emmetropia. -lOdpt and corneal astigmatism up to 5 dpt can be corrected. eriods. I went for the consultation and surgery same day. ZEISS SMILE precalculates all intracorneal cuts necessary for the vision correction. [8] and Aǧca et al. Differences between baseline and follow-ups were tested with the Friedman test at a significance level with Bonferroni correction (1.25% for baseline, 1-month, 6-months, and 12-months follow-up; 1.67% for safety and efficacy index) followed by a post-hoc analysis using Wilcoxon test. ReLEx® SMILE represents the most significant advance in cornea refractive surgery since the introduction of LASIK more than 20 years ago. You can help Wikipedia by expanding it. Ratnin Gimbel อันนี้โรงพยาบาลชื่อดังด้านตา คุณพ่อ . สนใจทำ Relex smile มีแนะนำไหมครับ. This is called a lenticule. Talk with your ophthalmologist to determine which option is best for you. The value of cylinder decreased postoperatively on myopic astigmatic eyes with a median of -0.50D (IQR = (-0.75 to 0.00)) at 1 month, -0.25 D (IQR = (-0.75 to -0.25) at 6 months and -0.50 D (IQR = (-0.75 to 0.00) at 12 months. [12] showed similar results in 95% of cases. 2015;31:104–9. 2016;11(7):e0158176. White ring sign and sequential segmental terminal lenticular side cut dissection for uneventful and complete lenticular extraction in SMILE. The ophthalmologist will remove the lenticule through the incision. Pallikaris IG, Papatzanaki ME, Stathi EZ, Frenschock O, Georgiadis A. Laser in situ keratomileusis. Scinus Cell Expansion B.V. Biotechnology Research Bilthoven, Utrecht 933 followers cell expansion the easy way Friedman test showed significant differences among follow-ups (Statistic= 62.02, P-value<0.0001). ReLEx SMILE is a newer alternative to existing refractive eye surgeries like LASIK. Asia Pac J Ophthalmol. The SMILE technique is applied in two centers in Romania, one in Bucharest and the other one in Cluj, at the Oculens Clinique. Patients older than 18 years, with ocular astigmatism up to -5.00 diopters (D), spherical equivalent up to -10.00D, corrected distance visual acuity (CDVA) of 0.3 or better before the surgery, stable refraction for one year, a minimum calculated post operator residual stromal bed of 250μ, minimal preoperative pachymetry of 500 μm were included in the study. Campylobacter jejuni and C. coli, the primary agents of human bacterial gastroenteritis worldwide, are widespread in surface water. Corneal ectasia 6.5 months after small-incision lenticule extraction. Br J Ophthalmol. 2017;33(5):352–4. PubMed Shen Z, Shi K, Yu Y, Yu X, Lin Y, Yao K. Small incision lenticule extraction (SMILE) versus femtosecond laser-assisted in situ keratomileusis (FS-LASIK) for myopia:a systematic review and meta-analysis. Is only approved in the United States for correcting myopia (nearsightedness) and astigmatism. SDB helped to collect the data, made data curation and analysis and drafted the manuscript. J Cataract Refract Surg. At six months, 29 (43.3%) of myopic astigmatic eyes were maintained within ±0.5 D and 48 (71.6%) within ±1D. Spherical equivalent refraction, cylinder, UDVA and CDVA, and keratometry values were measured before the surgery (baseline) and at 1, 6 and 12 months after the procedure.
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